Leslie Orgel, The origin of life (1998)
Leslie Orgel, "The origin of life a review of facts and speculations," Trends in Biochemical Sciences 1998, vol. 23, s. 491–495.
"In my opinion, there is no basis in known chemistry for the belief that long sequences of reactions can organize spontaneously – and every reason to believe that they cannot. The problem of achieving sufficient specificity, whether in aqueous solution or on the surface of a mineral, is so severe that the chance of closing a cycle of reactions as complex as the reverse citric acid cycle, for example, is negligible."