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File Andreas Lange et al., "Structural and functional characterization of a putative de novo gene in Drosophila"
NATURE COMMUNICATIONS | (2021) 12:1667 | | | Comparative genomic studies have repeatedly shown that new protein-coding genes can emerge de novo from noncoding DNA. Still unknown is how and when the structures of encoded de novo proteins emerge and evolve. Combining biochemical, genetic and evolutionary analyses, we elucidate the function and structure of goddard, a gene which appears to have evolved de novo at least 50 million years ago within the Drosophila genus. Previous studies found that goddard is required for male fertility. Here, we show that Goddard protein localizes to elongating sperm axonemes and that in its absence, elongated spermatids fail to undergo individualization. Combining modelling, NMR and circular dichroism (CD) data, we show that Goddard protein contains a large central α-helix, but is otherwise partially disordered. We find similar results for Goddard’s orthologs from divergent fly species and their reconstructed ancestral sequences. Accordingly, Goddard’s structure appears to have been maintained with only minor changes over millions of years.
Document Stephanie Pappas, "What fueled humans' big brains? Controversial paper proposes new hypothesis" W plejstocenie, od 2,6 miliona lat temu do 11 700 lat temu, znacznie zwiekszył się mózg ludzki. Uczeni z uniwersytetu Tel Avivu postawili nową hipotezę: gdy zabrakło dużych zwierząt, mózg ludzki musiał się powiększyć, by umożliwić polowanie na mniejsze zwierzęta.
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